Scenic view of Nashville skyline and pedestrian bridge reflecting in the Cumberland River at sunrise.

American Cruise Lines

Upper Mississippi River Cruise

US Rivers

Sailing Itinerary

Pricing

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Trip Details

Departs: October 11, 2029

Returns: October 19, 2029

Departure Port: St. Louis

Ship: American Symphony

Before You Decide

3 other departures of this route

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6 cruises leaving the same week

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Your Ship

American Symphony

The riverboat with the widest range in the fleet, and a Gulf Coast week that leaves the river entirely

Aboard

Fifth of American Cruise Lines' modern riverboats, delivered in 2022
A four-story glass atrium through the middle of the ship
Fifth-deck skywalk with an elliptical skylight over the Ellipse Café below
An opening bow and retractable gangway, she lands on the levee itself
Works the Tennessee, the Cumberland, the Ohio, both Mississippis and the Arkansas
A winter Gulf Coast run from New Orleans to Pensacola, on salt water

More About American Symphony

US Rivers

America's Rivers

The Mississippi, the Columbia and the Snake aboard small ships that dock in the middle of town: no passport, no flight over an ocean, and a different American city every morning.

Best Time to Go: April to November, with fall color on the Mississippi in October
Typical Length: 7 to 15 nights

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The Same Trip, Other Weeks

The identical itinerary on this ship, priced by departure. Fares move week to week, and the difference is often larger than anything else on this page.