Scenic view of Nashville skyline and pedestrian bridge reflecting in the Cumberland River at sunrise.

American Cruise Lines

Lower Mississippi River Cruise

US Rivers

Sailing Itinerary

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Your Ship

American Serenade

The Mississippi end to end, from Memphis and St. Louis, and one of the three boats opening up the Arkansas

Aboard

  • Sixth of the line's modern riverboats, and one of the three with the Sky Walk top deck
  • 91 staterooms for 180 guests, all of them with private step-out balconies
  • An eight-foot draft, shallow enough for the Arkansas River as far up as Tulsa
  • Named best new river ship in Cruise Critic's 2023 Editors' Picks
  • Memphis to New Orleans on the lower river most weeks, St. Louis to St. Paul on the upper
  • A run up the Arkansas from Tulsa to Little Rock, on a river with no cruise history at all

Ashore

Where You Stop

New Orleans

US Rivers

America's Rivers

The Mississippi, the Columbia and the Snake aboard small ships that dock in the middle of town: no passport, no flight over an ocean, and a different American city every morning.

Best Time to Go
April to November, with fall color on the Mississippi in October
Typical Length
7 to 15 nights
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Compare Dates

The Same Trip, Other Weeks

The identical itinerary on this ship, priced by departure. Fares move week to week, and the difference is often larger than anything else on this page.

DepartsFrom
October 15, 2026
October 22, 2026This sailing
February 19, 2027
February 26, 2027
March 5, 2027
March 12, 2027
March 19, 2027
March 26, 2027
April 2, 2027
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April 30, 2027